Senior author Rohit Kulkarni, M.D., Ph.D., at the Joslin Diabetes Center and Associate Professor of Medicine at Harvard Medical School, said that complications were a major cause of serious diseases in type 1 diabetes, which affect the cardiovascular system, kidneys, eyes and nerves.
Even with very good glycemic control, people with type 1 diabetes could still develop complications that impact their ability to work and quality of life.In the study, induced pluripotent stem (iPS) cells, which have the potential to differentiate into any type of cell in the body, were used to model the disease.
They were derived from skin cells obtained from patients who have had type 1 diabetes for 50 years or more and are members of the Joslin 50-Year Medalist Program, and also from healthy controls.
Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes. Only 5% of people with diabetes have this form of the disease.In type 1 diabetes, the body does not produce insulin. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life. With the help of insulin therapy and other treatments, even young children can learn to manage their condition and live long, healthy lives.
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